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Titel:

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Raad, Nour; Bittihn, Philip; Cacheux, Marine; Jeong, Dongtak; Ilkan, Zeki; Ceholski, Delaine; Kohlbrenner, Erik; Zhang, Lu; Cai, Chen-Leng; Kranias, Evangelia G; Hajjar, Roger J; Stillitano, Francesca; Akar, Fadi G
Abstract:
BACKGROUND: Arginine (Arg) 14 deletion (R14del) in the calcium regulatory protein phospholamban (hPLNR14del) has been identified as a disease-causing mutation in patients with an inherited cardiomyopathy. Mechanisms underlying the early arrhythmogenic phenotype that predisposes carriers of this mutation to sudden death with no apparent structural remodeling remain unclear. METHODS: To address this, we performed high spatiotemporal resolution optical mapping of intact hearts from adult knock-in m...     »
Zeitschriftentitel:
Circulation
Jahr:
2021
Band / Volume:
144
Heft / Issue:
6
Seitenangaben Beitrag:
441-454
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.119.043502
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34024116
Print-ISSN:
0009-7322
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin I, Kardiologie
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