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Title:

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Raad, Nour; Bittihn, Philip; Cacheux, Marine; Jeong, Dongtak; Ilkan, Zeki; Ceholski, Delaine; Kohlbrenner, Erik; Zhang, Lu; Cai, Chen-Leng; Kranias, Evangelia G; Hajjar, Roger J; Stillitano, Francesca; Akar, Fadi G
Abstract:
BACKGROUND: Arginine (Arg) 14 deletion (R14del) in the calcium regulatory protein phospholamban (hPLNR14del) has been identified as a disease-causing mutation in patients with an inherited cardiomyopathy. Mechanisms underlying the early arrhythmogenic phenotype that predisposes carriers of this mutation to sudden death with no apparent structural remodeling remain unclear. METHODS: To address this, we performed high spatiotemporal resolution optical mapping of intact hearts from adult knock-in m...     »
Journal title abbreviation:
Circulation
Year:
2021
Journal volume:
144
Journal issue:
6
Pages contribution:
441-454
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.119.043502
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34024116
Print-ISSN:
0009-7322
TUM Institution:
Klinik und Poliklinik für Innere Medizin I, Kardiologie
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