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Title:

Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism.

Document type:
Article; Journal Article
Author(s):
von Scheidt, Moritz; Zhao, Yuqi; de Aguiar Vallim, Thomas Q; Che, Nam; Wierer, Michael; Seldin, Marcus M; Franzén, Oscar; Kurt, Zeyneb; Pang, Shichao; Bongiovanni, Dario; Yamamoto, Masayuki; Edwards, Peter A; Ruusalepp, Arno; Kovacic, Jason C; Mann, Matthias; Björkegren, Johan L M; Lusis, Aldons J; Yang, Xia; Schunkert, Heribert
Abstract:
BACKGROUND: Coronary artery disease (CAD) is a multifactorial condition with both genetic and exogenous causes. The contribution of tissue-specific functional networks to the development of atherosclerosis remains largely unclear. The aim of this study was to identify and characterize central regulators and networks leading to atherosclerosis. METHODS: Based on several hundred genes known to affect atherosclerosis risk in mouse (as demonstrated in knockout models) and human (as shown by genome-w...     »
Journal title abbreviation:
Circulation
Year:
2021
Journal volume:
143
Journal issue:
18
Pages contribution:
1809-1823
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.120.050186
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33626882
Print-ISSN:
0009-7322
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Innere Medizin I, Kardiologie
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