Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Louadi, Zakaria; Elkjaer, Maria L; Klug, Melissa; Lio, Chit Tong; Fenn, Amit; Illes, Zsolt; Bongiovanni, Dario; Baumbach, Jan; Kacprowski, Tim; List, Markus; Tsoy, Olga
Abstract:
Alternative splicing (AS) is an important aspect of gene regulation. Nevertheless, its role in molecular processes and pathobiology is far from understood. A roadblock is that tools for the functional analysis of AS-set events are lacking. To mitigate this, we developed NEASE, a tool integrating pathways with structural annotations of protein-protein interactions to functionally characterize AS events. We show in four application cases how NEASE can identify pathways contributing to tissue ident...     »
Zeitschriftentitel:
Genome Biol
Jahr:
2021
Band / Volume:
22
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s13059-021-02538-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34857024
Print-ISSN:
1474-7596
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin I, Kardiologie
 BibTeX