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Title:

DGK and DZHK position paper on genome editing: basic science applications and future perspective.

Document type:
Review; Journal Article; Review
Author(s):
Brandes, Ralf P; Dueck, Anne; Engelhardt, Stefan; Kaulich, Manuel; Kupatt, Christian; De Angelis, Maria Teresa; Leisegang, Matthias S; le Noble, Ferdinand; Moretti, Alessandra; Müller, Oliver J; Skryabin, Boris V; Thum, Thomas; Wurst, Wolfgang
Abstract:
For a long time, gene editing had been a scientific concept, which was limited to a few applications. With recent developments, following the discovery of TALEN zinc-finger endonucleases and in particular the CRISPR/Cas system, gene editing has become a technique applicable in most laboratories. The current gain- and loss-of function models in basic science are revolutionary as they allow unbiased screens of unprecedented depth and complexity and rapid development of transgenic animals. Modifica...     »
Journal title abbreviation:
Basic Res Cardiol
Year:
2021
Journal volume:
116
Journal issue:
1
Fulltext / DOI:
doi:10.1007/s00395-020-00839-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33449167
Print-ISSN:
0300-8428
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; Institut für Pharmakologie und Toxikologie; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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