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Titel:

Osteoidosis leads to altered differentiation and function of osteoclasts.

Dokumenttyp:
Journal Article
Autor(en):
Grünherz, Lisanne; Prein, Carina; Winkler, Thomas; Kirsch, Manuela; Hopfner, Ursula; Streichert, Thomas; Clausen-Schaumann, Hauke; Zustin, Jozef; Kirchhof, Kristin; Morlock, Michael M; Machens, Hans-Günter; Schilling, Arndt Friedrich
Abstract:
In patients with osteomalacia, a defect in bone mineralization leads to changed characteristics of the bone surface. Considering that the properties of the surrounding matrix influence function and differentiation of cells, we aimed to investigate the effect of osteoidosis on differentiation and function of osteoclasts. Based on osteomalacic bone biopsies, a model for osteoidosis in vitro (OIV) was established. Peripheral blood mononuclear cells were differentiated to osteoclasts on mineralized...     »
Zeitschriftentitel:
J Cell Mol Med
Jahr:
2020
Band / Volume:
24
Heft / Issue:
10
Seitenangaben Beitrag:
5665-5674
Volltext / DOI:
doi:10.1111/jcmm.15227
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32283567
Print-ISSN:
1582-1838
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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