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Title:

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

Document type:
Journal Article
Author(s):
Götzl, Julia K; Brendel, Matthias; Werner, Georg; Parhizkar, Samira; Sebastian Monasor, Laura; Kleinberger, Gernot; Colombo, Alessio-Vittorio; Deussing, Maximilian; Wagner, Matias; Winkelmann, Juliane; Diehl-Schmid, Janine; Levin, Johannes; Fellerer, Katrin; Reifschneider, Anika; Bultmann, Sebastian; Bartenstein, Peter; Rominger, Axel; Tahirovic, Sabina; Smith, Scott T; Madore, Charlotte; Butovsky, Oleg; Capell, Anja; Haass, Christian
Abstract:
Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Among these genes are progranulin (GRN) and the triggering receptor expressed on myeloid cells 2 (TREM2). Both cause neurodegeneration by me...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2019
Journal volume:
11
Journal issue:
6
Fulltext / DOI:
doi:10.15252/emmm.201809711
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31122931
Print-ISSN:
1757-4676
TUM Institution:
617; Institut für Humangenetik; Klinik und Poliklinik für Psychiatrie und Psychotherapie; Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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