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Title:

Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis.

Document type:
Article; Journal Article
Author(s):
Schulte, Rike; Wohlleber, Dirk; Unrau, Ludmilla; Geers, Bernd; Metzger, Christina; Erhardt, Annette; Tiegs, Gisa; van Rooijen, Nico; Heukamp, Lukas C; Klotz, Luisa; Knolle, Percy A; Diehl, Linda
Abstract:
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) regulates target gene expression upon ligand binding. Apart from its effects on metabolism, PPARγ activity can inhibit the production of pro-inflammatory cytokines by several immune cells, including dendritic cells and macrophages. In chronic inflammatory disease models, PPARγ activation delays the onset and ameliorates disease severity. Here, we investigated the effect of PPARγ activation by the agonist Pioglitazone o...     »
Journal title abbreviation:
Int J Mol Sci
Year:
2020
Journal volume:
21
Journal issue:
7
Fulltext / DOI:
doi:10.3390/ijms21072523
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32260486
Print-ISSN:
1422-0067
TUM Institution:
1533; Institut für Experimentelle Onkologie und Therapieforschung; Roman Herzog Comprehensive Cancer Center
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