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Title:

Abnormal lipid composition of microsomes from cirrhotic rat liver--does it contribute to decreased microsomal function?

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Reichen, J; Buters, J T; Sojcic, Z; Roos, F J
Abstract:
We determined to what extent a change in the lipid composition of the smooth endoplasmic reticulum contributes to altered microsomal function in cirrhosis. Rats were rendered cirrhotic either by chronic exposure to phenobarbital/CCl4 (MCIR) or by bile duct ligation (BCIR). Microsomal function was tested in vivo by the aminopyrine breath test (ABT), then microsomes were prepared and their phospholipid and cholesterol composition analysed. ABT was reduced by 35 and 41% in BCIR and MCIR, respective...     »
Journal title abbreviation:
Experientia
Year:
1992
Journal volume:
48
Journal issue:
5
Pages contribution:
482-6
Fulltext / DOI:
doi:10.1007/bf01928168
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/1601113
Print-ISSN:
0014-4754
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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