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Title:

Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model.

Document type:
Journal Article
Author(s):
Beller, Ebba; Reuter, Laura; Kluge, Anne; Preibisch, Christine; Lindauer, Ute; Bogdanov, Alexei; Lämmer, Friederike; Delbridge, Claire; Matiasek, Kaspar; Schwaiger, Benedikt J; Boeckh-Behrens, Tobias; Zimmer, Claus; Gersing, Alexandra S
Abstract:
After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obtained by MRI during MCAO. DWI, T2- and T1-weighted images with and withou...     »
Journal title abbreviation:
Sci Rep
Year:
2018
Journal volume:
8
Journal issue:
1
Pages contribution:
745
Fulltext / DOI:
doi:10.1038/s41598-017-17533-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29335483
Print-ISSN:
2045-2322
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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