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Title:

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Document type:
Journal Article; Article
Author(s):
Renner, Simone; Blutke, Andreas; Dobenecker, Britta; Dhom, Georg; Müller, Timo D; Finan, Brian; Clemmensen, Christoffer; Bernau, Maren; Novak, Istvan; Rathkolb, Birgit; Senf, Steffanie; Zöls, Susanne; Roth, Mirjam; Götz, Anna; Hofmann, Susanna M; Hrab? de Angelis, Martin; Wanke, Rüdiger; Kienzle, Ellen; Scholz, Armin M; DiMarchi, Richard; Ritzmann, Mathias; Tschöp, Matthias H; Wolf, Eckhard
Abstract:
The worldwide prevalence of obesity has increased to 10% in men and 15% in women and is associated with severe comorbidities such as diabetes, cancer, and cardiovascular disease. Animal models of obesity are central to experimental studies of disease mechanisms and therapeutic strategies. Diet-induced obesity (DIO) models in rodents have provided important insights into the pathophysiology of obesity and, in most instances, are the first in line for exploratory pharmacology studies. To deepen th...     »
Journal title abbreviation:
Mol Metab
Year:
2018
Journal volume:
16
Pages contribution:
180-190
Fulltext / DOI:
doi:10.1016/j.molmet.2018.06.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30017782
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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