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Title:

Mir34a constrains pancreatic carcinogenesis.

Document type:
Journal Article
Author(s):
Hidalgo-Sastre, Ana; Lubeseder-Martellato, Clara; Engleitner, Thomas; Steiger, Katja; Zhong, Suyang; Desztics, Judit; Öllinger, Rupert; Rad, Roland; Schmid, Roland M; Hermeking, Heiko; Siveke, Jens T; von Figura, Guido
Abstract:
Several studies have shown that over 70 different microRNAs are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC), affecting proliferation, apoptosis, metabolism, EMT and metastasis. The most important genetic alterations driving PDAC are a constitutive active mutation of the oncogene Kras and loss of function of the tumour suppressor Tp53 gene. Since the MicroRNA 34a (Mir34a) is a direct target of Tp53 it may critically contribute to the suppression of PDAC. Mir34a is epigenetical...     »
Journal title abbreviation:
Sci Rep
Year:
2020
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-020-66561-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32541781
Print-ISSN:
2045-2322
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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