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Title:

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements.

Document type:
Journal Article
Author(s):
Spanopoulou, Anna; Heidrich, Luzia; Chen, Hong-Ru; Frost, Christina; Hrle, Dean; Malideli, Eleni; Hille, Kathleen; Grammatikopoulos, Alexandros; Bernhagen, Jürgen; Zacharias, Martin; Rammes, Gerhard; Kapurniotu, Aphrodite
Abstract:
Amyloid self-assembly is linked to the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), but so far, no anti-amyloid compound has reached the clinic. Macrocyclic peptides belong to the most attractive drug candidates. Herein we present macrocyclic peptides (MCIPs) designed using minimal IAPP-derived recognition elements as a novel class of nanomolar amyloid inhibitors of both A?40(42) and IAPP or A?40(42) alone and show that chirality controls inhibitor selectivity. Sequence op...     »
Journal title abbreviation:
Angew Chem Int Ed Engl
Year:
2018
Journal volume:
57
Journal issue:
44
Pages contribution:
14503-14508
Fulltext / DOI:
doi:10.1002/anie.201802979
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29908130
Print-ISSN:
1433-7851
TUM Institution:
Klinik für Anästhesiologie (DHM)
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