User: Guest  Login
Title:

Evaluation of MR-derived CT-like images and simulated radiographs compared to conventional radiography in patients with benign and malignant bone tumors.

Document type:
Journal Article
Author(s):
Gersing, Alexandra S; Pfeiffer, Daniela; Kopp, Felix K; Schwaiger, Benedikt J; Knebel, Carolin; Haller, Bernhard; Noël, Peter B; Settles, Marcus; Rummeny, Ernst J; Woertler, Klaus
Abstract:
To evaluate the diagnostic value of MR-derived CT-like images and simulated radiographs compared with conventional radiographs in patients with benign and malignant bone tumors.In 32 patients with a benign or malignant bone lesion (mean age 33.9 ± 18.5 years, 17 females), 3-T MR imaging was performed including a 3D T1-weighted gradient echo sequence as the basis for the CT-like images. From these, intensity-inverted MR image volumes were converted into 2D images via a forward projection to obtain simulated radiographs. Two radiologists assessed these images as well as conventional radiographs for the type of periosteal reaction, matrix mineralization and destruction pattern. Agreement between the modalities was calculated using Cohen's ?.The agreement between conventional radiographs and MR-derived CT-like images in combination with simulated radiographs was substantial (periosteal reaction, ? = 0.67; destruction pattern, ? = 0.75), and the sensitivity of both modalities for the final diagnosis of the lesion (aggressive vs. nonaggressive) was high (MR-derived CT-like images, 86.2% vs. conventional radiographs, 90.0%). Additional information on soft tissue extension (MR-derived CT-like images, 21.9% vs. conventional radiographs, 12.5%; p = 0.009) and lobulation (9.4% vs. 0%; p < 0.001) was significantly more often found on MR-derived CT-like images compared with conventional radiographs.The assessment of the destruction patterns, periosteal reaction and distinction between aggressive and nonaggressive tumors was feasible using MR-derived CT-like images and simulated radiographs and is comparable to that of conventional radiographs. Moreover, MR-derived CT-like images provided additional information on soft tissue extension and tumor architecture.o CT-like images and simulated radiographs can be generated from 3D MRI. o Evaluation of bone tumors is feasible with MR-derived images. o CT-like images and simulated radiographs provide additional information on bone tumors.
Journal title abbreviation:
Eur Radiol
Year:
2019
Journal volume:
29
Journal issue:
1
Pages contribution:
13-21
Fulltext / DOI:
doi:10.1007/s00330-018-5450-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29948069
Print-ISSN:
0938-7994
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Orthopädie und Sportorthopädie
 BibTeX