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Title:

Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4.

Document type:
Journal Article
Author(s):
Gelboin, H V; Krausz, K W; Goldfarb, I; Buters, J T; Yang, S K; Gonzalez, F J; Korzekwa, K R; Shou, M
Abstract:
Cytochromes P450 3A3/4 are inordinately important P450 enzymes catalyzing the metabolism of a large variety of clinically useful drugs, steroids, and carcinogens. Two monoclonal antibodies, MAb 3-29-9 and MAb 275-1-2, were prepared to human P450 3A4 from mice immunized with baculovirus-expressed human P450 3A4. MAb 3-29-9 was a powerful inhibitor of the enzymatic activity of P450 3A3/4/5. MAb 3-29-9 inhibited the P450 3A3, 3A4, and 3A5 catalyzed metabolism of substrates of divergent molecular we...     »
Journal title abbreviation:
Biochem Pharmacol
Year:
1995
Journal volume:
50
Journal issue:
11
Pages contribution:
1841-50
Fulltext / DOI:
doi:10.1016/0006-2952(95)02077-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/8615863
Print-ISSN:
0006-2952
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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