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Titel:

Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374.

Dokumenttyp:
Comparative Study; Journal Article
Autor(en):
Crespi, C L; Steimel, D T; Penman, B W; Korzekwa, K R; Fernandez-Salguero, P; Buters, J T; Gelboin, H V; Gonzalez, F J; Idle, J R; Daly, A K
Abstract:
We have analysed kinetic parameters of cDNA-derived CYP2D6 proteins derived from the original CYP2D6 cDNA isolate (Gonzalez FJ et al. Nature 1988: 331, 442-446) which contains methionine at position 374 (CYP2D6-Met) and a modified cDNA which contains valine at position 374 (CYP2D6-Val). This latter protein is predicted from the CYP2D6 genomic sequence. Several quantitative differences, but no qualitative differences in metabolism were observed. CYP2D6-Met was found to have a two-fold lower Km an...     »
Zeitschriftentitel:
Pharmacogenetics
Jahr:
1995
Band / Volume:
5
Heft / Issue:
4
Seitenangaben Beitrag:
234-43
Volltext / DOI:
doi:10.1097/00008571-199508000-00007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/8528270
Print-ISSN:
0960-314X
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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