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Title:

The three common polymorphisms p.A986S, p.R990G and p.Q1011E in the calcium sensing receptor (CASR) are not associated with chronic pancreatitis.

Document type:
Article; Journal Article
Author(s):
Ewers, Maren; Canaff, Lucie; Weh, Antonia Em; Masson, Emmanuelle; Eiseler, Katharina; Chen, Jian-Min; Rebours, Vinciane; Bugert, Peter; Michl, Patrick; Rosendahl, Jonas; Férec, Claude; Goltzman, David; Witt, Heiko
Abstract:
BACKGROUND: The calcium sensing receptor (CASR) is a G protein-coupled receptor that is responsible for assessing extracellular Ca2+ levels and thus plays a crucial role in calcium homeostasis. Hypercalcemia is a metabolic risk factor for pancreatitis and rare CASR variants have been described in patients with chronic pancreatitis. At the carboxy-terminal tail of CASR, there is a cluster of three common polymorphisms, p.A986S (rs1801725), p.R990G (rs1042636) and p.Q1011E (rs1801726), which have...     »
Journal title abbreviation:
Pancreatology
Year:
2021
Journal volume:
21
Journal issue:
7
Pages contribution:
1299-1304
Fulltext / DOI:
doi:10.1016/j.pan.2021.08.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34446336
Print-ISSN:
1424-3903
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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