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Dokumenttyp:
Article; Journal Article
Autor(en):
Laber, Samantha; Forcisi, Sara; Bentley, Liz; Petzold, Julia; Moritz, Franco; Smirnov, Kirill S; Al Sadat, Loubna; Williamson, Iain; Strobel, Sophie; Agnew, Thomas; Sengupta, Shahana; Nicol, Tom; Grallert, Harald; Heier, Margit; Honecker, Julius; Mianne, Joffrey; Teboul, Lydia; Dumbell, Rebecca; Long, Helen; Simon, Michelle; Lindgren, Cecilia; Bickmore, Wendy A; Hauner, Hans; Schmitt-Kopplin, Philippe; Claussnitzer, Melina; Cox, Roger D
Titel:
Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
Abstract:
Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates Irx3 and Irx5 gene expression and mitochondrial function in adipocytes. The CRM affects molecular and cellular phenotypes in an adipose depot-dependent manner and affects organismal phenotypes that are...     »
Zeitschriftentitel:
Sci Adv
Jahr:
2021
Band / Volume:
7
Heft / Issue:
30
Volltext / DOI:
doi:10.1126/sciadv.abg0108
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34290091
Print-ISSN:
2375-2548
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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