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Titel:

Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS.

Dokumenttyp:
Journal Article
Autor(en):
Syväri, Jan; Ruschke, Stefan; Dieckmeyer, Michael; Hauner, Hans H; Junker, Daniela; Makowski, Marcus R; Baum, Thomas; Karampinos, Dimitrios C
Abstract:
PURPOSE: To define a metric for the separability between water and olefinic fat peaks that defines a threshold beyond which the extraction of the olefinic fat peak from vertebral bone marrow short-echo time-stimulated echo acquisition mode MRS at 3T is feasible when using a constrained peak fitting based on the triglyceride fat model. METHODS: The water and olefinic peak height difference was defined as a metric for quantifying the separability of water and olefinic fat peaks. Fat unsaturation was determined using an unconstrained olefinic peak fitting and a constrained fitting of all fat peaks to the triglyceride model. The agreement between the two peak-fitting methods was used to define a threshold on water and olefinic peak height difference separating two groups (A and B), based on L5 short-echo time-stimulated echo acquisition mode (TE = 11 ms) spectra from 252 subjects measured at 3T. RESULTS: A threshold on water and olefinic peak height difference was defined. Group A with a good agreement of the olefinic fat peak between the two peak-fitting methods showed a mean number of double bounds = 2.95 ± 0.21, a mean number of methylene-interrupted double bounds = 0.94 ± 0.16 and also a significantly lower coefficient of variation for all fatty acid composition parameters compared to group B (p < .001). The water and olefinic peak height difference value showed an inverse association with fat fraction. CONCLUSION: A threshold of a metric quantifying the separability of the water peak and the olefinic fat peaks was defined for the estimation of the vertebral bone marrow fat unsaturation from short-echo time-stimulated echo acquisition mode MRS. The proposed methodology shows that the assessment of vertebral bone marrow unsaturation is feasible with a short-echo time-stimulated echo acquisition mode MRS in subjects with a higher fat fraction.
Zeitschriftentitel:
Magn Reson Med
Jahr:
2021
Band / Volume:
85
Heft / Issue:
2
Seitenangaben Beitrag:
615-626
Volltext / DOI:
doi:10.1002/mrm.28453
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32783232
Print-ISSN:
0740-3194
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Fachgebiet Neuroradiologie (Prof. Zimmer)
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