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Titel:

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Krane, Markus; Dreßen, Martina; Santamaria, Gianluca; My, Ilaria; Schneider, Christine M; Dorn, Tatjana; Laue, Svenja; Mastantuono, Elisa; Berutti, Riccardo; Rawat, Hilansi; Gilsbach, Ralf; Schneider, Pedro; Lahm, Harald; Schwarz, Sascha; Doppler, Stefanie A; Paige, Sharon; Puluca, Nazan; Doll, Sophia; Neb, Irina; Brade, Thomas; Zhang, Zhong; Abou-Ajram, Claudia; Northoff, Bernd; Holdt, Lesca M; Sudhop, Stefanie; Sahara, Makoto; Goedel, Alexander; Dendorfer, Andreas; Tjong, Fleur V Y; Rijlaarsda...     »
Abstract:
BACKGROUND: Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects occurring in association with ventricular hypoplasia. The pathogenesis of HLHS is unknown, but hemodynamic disturbances are assumed to play a prominent role. METHODS: To identify perturbations in gene programs controlling ventricular muscle linea...     »
Zeitschriftentitel:
Circulation
Jahr:
2021
Band / Volume:
144
Heft / Issue:
17
Seitenangaben Beitrag:
1409-1428
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.121.056198
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34694888
Print-ISSN:
0009-7322
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; Institut für Humangenetik; Klinik für Herz- und Gefäßchirurgie (Prof. Lange); Klinik und Poliklinik für Innere Medizin I, Kardiologie
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