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Title:

Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Author(s):
Matthias, Julia; Heink, Sylvia; Picard, Felix; Zeiträg, Julia; Kolz, Anna; Chao, Ying-Yin; Soll, Dominik; de Almeida, Gustavo P; Glasmacher, Elke; Jacobsen, Ilse D; Riedel, Thomas; Peters, Anneli; Floess, Stefan; Huehn, Jochen; Baumjohann, Dirk; Huber, Magdalena; Korn, Thomas; Zielinski, Christina E
Abstract:
Th cells integrate signals from their microenvironment to acquire distinct specialization programs for efficient clearance of diverse pathogens or for immunotolerance. Ionic signals have recently been demonstrated to affect T cell polarization and function. Sodium chloride (NaCl) was proposed to accumulate in peripheral tissues upon dietary intake and to promote autoimmunity via the Th17 cell axis. Here, we demonstrate that high-NaCl conditions induced a stable, pathogen-specific, antiinflammato...     »
Journal title abbreviation:
J Clin Invest
Year:
2020
Journal volume:
130
Journal issue:
9
Pages contribution:
4587-4600
Fulltext / DOI:
doi:10.1172/JCI137786
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32484796
Print-ISSN:
0021-9738
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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