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Titel:

Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Dietrich, Michael; Koska, Valeria; Hecker, Christina; Göttle, Peter; Hilla, Alexander M; Heskamp, Annemarie; Lepka, Klaudia; Issberner, Andrea; Hallenberger, Angelika; Baksmeier, Christine; Steckel, Julia; Balk, Lisanne; Knier, Benjamin; Korn, Thomas; Havla, Joachim; Martínez-Lapiscina, Elena H; Solà-Valls, Nuria; Manogaran, Praveena; Olbert, Elisabeth D; Schippling, Sven; Cruz-Herranz, Andrés; Yiu, Hao; Button, Julia; Caldito, Natalia Gonzalez; von Gall, Charlotte; Mausberg, Anne K; Stettner, M...     »
Abstract:
Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action is via blockade of axonal voltage gated potassium channels, thereby enhancing conduction in demyelinated axons. In this study, we provide evidence that in addition to those symptomatic effects, 4-AP can prevent neuroaxonal loss in the CNS. Using in vivo optical...     »
Zeitschriftentitel:
Brain
Jahr:
2020
Band / Volume:
143
Heft / Issue:
4
Seitenangaben Beitrag:
1127-1142
Volltext / DOI:
doi:10.1093/brain/awaa062
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32293668
Print-ISSN:
0006-8950
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle)
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