User: Guest  Login
Title:

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.

Document type:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Kim, Teayoun; Nason, Shelly; Holleman, Cassie; Pepin, Mark; Wilson, Landon; Berryhill, Taylor F; Wende, Adam R; Steele, Chad; Young, Martin E; Barnes, Stephen; Drucker, Daniel J; Finan, Brian; DiMarchi, Richard; Perez-Tilve, Diego; Tschöp, Matthias; Habegger, Kirk M
Abstract:
Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion. However, FGF21 is only a partial mediator of metabolic actions ensuing from glucagon receptor (GCGR) activation, prompting us to search for additional pathways. Intriguingly, chronic GCGR agonism increases plasma bile acid levels. We hypothesized that GCGR agonism regulates energy metabolism, at least in part, through farnesoi...     »
Journal title abbreviation:
Diabetes
Year:
2018
Journal volume:
67
Journal issue:
9
Pages contribution:
1773-1782
Fulltext / DOI:
doi:10.2337/db17-1502
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29925501
Print-ISSN:
0012-1797
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
 BibTeX