Epigenetic germline inheritance of diet-induced obesity and insulin resistance.

Title:: Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
Document type:: Journal Article; Article
Author(s):: Huypens, Peter; Sass, Steffen; Wu, Moya; Dyckhoff, Daniela; Tschöp, Matthias; Theis, Fabian; Marschall, Susan; Hrab? de Angelis, Martin; Beckers, Johannes
Abstract:: There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
Journal title abbreviation:: Nat Genet
Year:: 2016
Journal volume:: 48
Journal issue:: 5
Pages contribution:: 497-9
Fulltext / DOI:: doi:10.1038/ng.3527
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/26974008
Print-ISSN:: 1061-4036
TUM Institution:: Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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