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Titel:

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Lockie, SH; Heppner, KM; Chaudhary, N; Chabenne, JR; Morgan, DA; Veyrat-Durebex, C; Ananthakrishnan, G; Rohner-Jeanrenaud, F; Drucker, DJ; DiMarchi, R; Rahmouni, K; Oldfield, BJ; Tschöp, MH; Perez-Tilve, D
Abstract:
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like peptide 1 receptor (GLP-1R)-deficient mice after the administration of the proglucagon-derived peptides (PGDPs) glucagon-like peptide (GLP-1), glucagon (GCG), and oxyntomodulin (OXM) directly into the brain. Intracerebroventricular injection of PGDPs reduces body weight and increases iBAT thermogenesis. This was independent of changes in feeding and insulin responsiveness but correlated with increas...     »
Zeitschriftentitel:
Diabetes
Jahr:
2012
Band / Volume:
61
Heft / Issue:
11
Seitenangaben Beitrag:
2753-62
Volltext / DOI:
doi:10.2337/db11-1556
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22933116
Print-ISSN:
0012-1797
TUM Einrichtung:
Kliniken und Institute
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