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Title:

Notch and TLR signaling coordinate monocyte cell fate and inflammation.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gamrekelashvili, Jaba; Kapanadze, Tamar; Sablotny, Stefan; Ratiu, Corina; Dastagir, Khaled; Lochner, Matthias; Karbach, Susanne; Wenzel, Philip; Sitnow, Andre; Fleig, Susanne; Sparwasser, Tim; Kalinke, Ulrich; Holzmann, Bernhard; Haller, Hermann; Limbourg, Florian P
Abstract:
Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6Chi monocytes, and the resultant inflammation, is coordinately regulated by TLR and Notch signaling. Cell-intrinsic Notch2 and TLR7-Myd88 pathways independently and synergistically promote Ly6Clo patrolling monocyte develo...     »
Journal title abbreviation:
Elife
Year:
2020
Journal volume:
9
Fulltext / DOI:
doi:10.7554/eLife.57007
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32723480
TUM Institution:
Chirurgische Klinik und Poliklinik
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