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Titel:

ALDH1A3 Accelerates Pancreatic Cancer Metastasis by Promoting Glucose Metabolism.

Dokumenttyp:
Article; Journal Article
Autor(en):
Nie, Shuang; Qian, Xuetian; Shi, Mengyue; Li, Hongzhen; Peng, Chunyan; Ding, Xiwei; Zhang, Shu; Zhang, Bin; Xu, Guifang; Lv, Ying; Wang, Lei; Friess, Helmut; Kong, Bo; Zou, Xiaoping; Shen, Shanshan
Abstract:
Background: The aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a key enzyme associated with a variety of metabolic processes, including glucose metabolism. We recently uncovered that glucose metabolism played an essential role in promoting metastasis of pancreatic ductal adenocarcinoma (PDAC). As ALDH1A3 labels an aggressive subtype of PDAC, we hypothesized that ALDH1A3 functionally promoted PDAC metastasis via its metabolic effect on glucose metabolism. Methods: Expression of ALDH1A3 wa...     »
Zeitschriftentitel:
Front Oncol
Jahr:
2020
Band / Volume:
10
Volltext / DOI:
doi:10.3389/fonc.2020.00915
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32612951
Print-ISSN:
2234-943X
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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