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Titel:

Establishment and characterization of induced pluripotent stem cells (iPSCs) from central nervous system lupus erythematosus.

Dokumenttyp:
Article; Journal Article
Autor(en):
De Angelis, Maria Teresa; Santamaria, Gianluca; Parrotta, Elvira Immacolata; Scalise, Stefania; Lo Conte, Michela; Gasparini, Sara; Ferlazzo, Edoardo; Aguglia, Umberto; Ciampi, Clara; Sgura, Antonella; Cuda, Giovanni
Abstract:
Involvement of the central nervous system (CNS) is an uncommon feature in systemic lupus erythematosus (SLE), making diagnosis rather difficult and challenging due to the poor specificity of neuropathic symptoms and neurological symptoms. In this work, we used human-induced pluripotent stem cells (hiPSCs) derived from CNS-SLE patient, with the aim to dissect the molecular insights underlying the disease by gene expression analysis and modulation of implicated pathways. CNS-SLE-derived hiPSCs all...     »
Zeitschriftentitel:
J Cell Mol Med
Jahr:
2019
Band / Volume:
23
Heft / Issue:
11
Seitenangaben Beitrag:
7382-7394
Volltext / DOI:
doi:10.1111/jcmm.14598
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31536674
Print-ISSN:
1582-1838
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin
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