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Title:

Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Sumer, Simon Alexander; Hoffmann, Sandra; Laue, Svenja; Campbell, Birgit; Raedecke, Kristin; Frajs, Viktoria; Clauss, Sebastian; Kääb, Stefan; Janssen, Johannes W G; Jauch, Anna; Laugwitz, Karl-Ludwig; Dorn, Tatjana; Moretti, Alessandra; Rappold, Gudrun A
Abstract:
Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutation is crucial. Here, we generated and corrected hiPSC lines from two AF patients carrying different heterozygous SHOX2 mutations. We developed a strategy for the scarless correction of heterozygous m...     »
Journal title abbreviation:
Stem Cell Reports
Year:
2020
Journal volume:
15
Journal issue:
4
Pages contribution:
999-1013
Fulltext / DOI:
doi:10.1016/j.stemcr.2020.08.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32976766
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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