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Titel:

Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Sumer, Simon Alexander; Hoffmann, Sandra; Laue, Svenja; Campbell, Birgit; Raedecke, Kristin; Frajs, Viktoria; Clauss, Sebastian; Kääb, Stefan; Janssen, Johannes W G; Jauch, Anna; Laugwitz, Karl-Ludwig; Dorn, Tatjana; Moretti, Alessandra; Rappold, Gudrun A
Abstract:
Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutation is crucial. Here, we generated and corrected hiPSC lines from two AF patients carrying different heterozygous SHOX2 mutations. We developed a strategy for the scarless correction of heterozygous m...     »
Zeitschriftentitel:
Stem Cell Reports
Jahr:
2020
Band / Volume:
15
Heft / Issue:
4
Seitenangaben Beitrag:
999-1013
Volltext / DOI:
doi:10.1016/j.stemcr.2020.08.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32976766
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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