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Titel:

Domain zipping and unzipping modulates TRPM4's properties in human cardiac conduction disease.

Dokumenttyp:
Article; Journal Article
Autor(en):
Xian, Wenying; Wang, Hongmei; Moretti, Alessandra; Laugwitz, Karl-Ludwig; Flockerzi, Veit; Lipp, Peter
Abstract:
The transient receptor potential melastatin 4 (TRPM4) is a Ca2+ -activated nonselective cation channel linked to human cardiac diseases. The human mutation K914R within TRPM4's S4-S5 linker was identified in patients with atrioventricular block. During UV-flash-mediated Ca2+ transients, TRPM4K914R  generated a threefold augmented membrane current concomitant with 2 to 3-fold slowed down activation and deactivation kinetics resulting in excessive membrane currents during human cardiac action pote...     »
Zeitschriftentitel:
FASEB J
Jahr:
2020
Band / Volume:
34
Heft / Issue:
9
Seitenangaben Beitrag:
12114-12126
Volltext / DOI:
doi:10.1096/fj.202000097RR
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32681584
Print-ISSN:
0892-6638
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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