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Title:

Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Faist, Benjamin; Schlott, Fabian; Stemberger, Christian; Dennehy, Kevin M; Krackhardt, Angela; Verbeek, Mareike; Grigoleit, Götz U; Schiemann, Matthias; Hoffmann, Dieter; Dick, Andrea; Martin, Klaus; Hildebrandt, Martin; Busch, Dirk H; Neuenhahn, Michael
Abstract:
Adoptive T cell therapy (ACT) has become a treatment option for viral reactivations in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). Animal models have shown that pathogen-specific central memory T cells (TCM) are protective even at low numbers and show long-term survival, extensive proliferation and high plasticity after adoptive transfer. Concomitantly, our own recent clinical data demonstrate that minimal doses of purified (not in-vitro- expanded) human CM...     »
Journal title abbreviation:
PLoS ONE
Year:
2019
Journal volume:
14
Journal issue:
9
Fulltext / DOI:
doi:10.1371/journal.pone.0223258
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31568490
Print-ISSN:
1932-6203
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Kliniken und Institute
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