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Title:

Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice.

Document type:
Journal Article
Author(s):
Bauer, C; Schillinger, U; Brandl, J; Meyer-Lindenberg, A; Ott, A; Baumgartner, C
Abstract:
In accordance with the 'refinement' component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide adequate surgical tolerance at a 50% dose relative to that of ketamine racemate and whether antagonism of medetomidine could be initiated 15 min earlier. The second aim was to investigate the potential impro...     »
Journal title abbreviation:
Lab Anim
Year:
2019
Journal volume:
53
Journal issue:
5
Pages contribution:
459-469
Fulltext / DOI:
doi:10.1177/0023677218815208
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30526293
Print-ISSN:
0023-6772
TUM Institution:
Kliniken und Institute
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