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Titel:

Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial.

Dokumenttyp:
Article; Journal Article
Autor(en):
Levin, Johannes; Maaß, Sylvia; Schuberth, Madeleine; Giese, Armin; Oertel, Wolfgang H; Poewe, Werner; Trenkwalder, Claudia; Wenning, Gregor K; Mansmann, Ulrich; Südmeyer, Martin; Eggert, Karla; Mollenhauer, Brit; Lipp, Axel; Löhle, Matthias; Classen, Joseph; Münchau, Alexander; Kassubek, Jan; Gandor, Florin; Berg, Daniela; Egert-Schwender, Silvia; Eberhardt, Cornelia; Paul, Friedemann; Bötzel, Kai; Ertl-Wagner, Birgit; Huppertz, Hans-Jürgen; Ricard, Ingrid; Höglinger, Günter U
Abstract:
BACKGROUND: Multiple system atrophy is a rare neurodegenerative disease characterised by aggregation of α-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gallate inhibits α-synuclein aggregation and reduces associated toxicity. We aimed to establish if epigallocatechin gallate could safely slow disease progression in patients with multiple system atrophy. METHODS: We did a randomised, double-blind, parallel group, placebo-controlled clinical trial at 12 specialist cent...     »
Zeitschriftentitel:
Lancet Neurol
Jahr:
2019
Band / Volume:
18
Heft / Issue:
8
Seitenangaben Beitrag:
724-735
Volltext / DOI:
doi:10.1016/S1474-4422(19)30141-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31278067
Print-ISSN:
1474-4422
TUM Einrichtung:
Kliniken und Institute; Neurologische Klinik und Poliklinik
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