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Title:

IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.

Document type:
Article; Journal Article
Author(s):
Lauffer, F; Jargosch, M; Baghin, V; Krause, L; Kempf, W; Absmaier-Kijak, M; Morelli, M; Madonna, S; Marsais, F; Lepescheux, L; Albanesi, C; Müller, N S; Theis, F J; Schmidt-Weber, C; Eyerich, S; Biedermann, T; Vandeghinste, N; Steidl, S; Eyerich, K
Abstract:
BACKGROUND: Key pathogenic events of psoriasis and atopic eczema (AE) are misguided immune reactions of the skin. IL-17C is an epithelial-derived cytokine, whose impact on skin inflammation is unclear. OBJECTIVE: We sought to characterize the role of IL-17C in human ISD. METHODS: IL-17C gene and protein expression was assessed by immunohistochemistry and transcriptome analysis. Primary human keratinocytes were stimulated and expression of cytokines chemokines was determined by qRT-PCR and lumine...     »
Journal title abbreviation:
J Eur Acad Dermatol Venereol
Year:
2020
Journal volume:
34
Journal issue:
4
Pages contribution:
800-809
Fulltext / DOI:
doi:10.1111/jdv.16126
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31793105
Print-ISSN:
0926-9959
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber); Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich)
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