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Title:

Gene Expression in Spontaneous Experimental Autoimmune Encephalomyelitis Is Linked to Human Multiple Sclerosis Risk Genes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Faber, Hans; Kurtoic, Dunja; Krishnamoorthy, Gurumoorthy; Weber, Peter; Pütz, Benno; Müller-Myhsok, Bertram; Weber, Frank; Andlauer, Till F M
Abstract:
Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expression profiling to study whether spontaneous opticospinal EAE (OSE) or MOG-induced EAE mirrors the genetic contribution to the pathogenesis of multiple sclerosis more faithfully. T...     »
Journal title abbreviation:
Front Immunol
Year:
2020
Journal volume:
11
Fulltext / DOI:
doi:10.3389/fimmu.2020.02165
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33072080
Print-ISSN:
1664-3224
TUM Institution:
Neurologische Klinik und Poliklinik
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