Microstructural Integrity of Salvaged Penumbra after Mechanical Thrombectomy.

Berndt, M T; Maegerlein, C; Boeckh-Behrens, T; Wunderlich, S; Zimmer, C; Wirth, S; Mück, F G; Mönch, S; Friedrich, B; Kaesmacher, J

doi:10.3174/ajnr.A6364

2020

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Title:: Microstructural Integrity of Salvaged Penumbra after Mechanical Thrombectomy.
Document type:: Journal Article
Author(s):: Berndt, M T; Maegerlein, C; Boeckh-Behrens, T; Wunderlich, S; Zimmer, C; Wirth, S; Mück, F G; Mönch, S; Friedrich, B; Kaesmacher, J
Abstract:: BACKGROUND AND PURPOSE: There are sparse data on the microstructural integrity of salvaged penumbral tissue after mechanical thrombectomy of large-vessel occlusions. The aim of the study was to analyze possible microstructural alteration in the penumbra and their association with clinical symptoms as well as angiographic reperfusion success in patients undergoing mechanical thrombectomy. MATERIALS AND METHODS: All patients who underwent mechanical thrombectomy for large-vessel occlusions in the anterior circulation and who received an admission CT perfusion together with postinterventional DTIs were included (n = 65). Angiographic reperfusion success by means of modified Thrombolysis in Cerebral Infarction (mTICI) scale and clinical outcome were recorded. Microstructural integrity was assessed by DTI evaluating the mean diffusivity index within the salvaged gray matter of the former penumbra. RESULTS: The mean diffusivity index was higher in completely recanalized patients (mTICI 3: -0.001 ± 0.034 versus mTICI <3: -0.030 ± 0.055, P = .03). There was a positive correlation between the mean diffusivity index and NIHSS score improvement (r = 0.49, P = .003) and the mean diffusivity index was associated with midterm functional outcome (r = -0.37, P = .04) after adjustment for confounders. In mediation analysis, the mean diffusivity index and infarction growth mediated the association between reperfusion success and clinical outcomes. CONCLUSIONS: The macroscopic salvaged penumbra included areas of microstructural integrity changes, most likely related to the initial hypoperfusion. These abnormalities were found early after mechanical thrombectomy, were dependent on angiographic results, and correlated with the clinical outcome. When confirmed, these findings prompt the evaluation of therapies for protection of the penumbral tissue integrity.
Journal title abbreviation:: AJNR Am J Neuroradiol
Year:: 2020
Journal volume:: 41
Journal issue:: 1
Pages contribution:: 79-85
Fulltext / DOI:: doi:10.3174/ajnr.A6364
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/31857324
Print-ISSN:: 0195-6108
TUM Institution:: Fachgebiet Neuroradiologie (Prof. Zimmer); Neurologische Klinik und Poliklinik
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