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Titel:

Gene Expression in Spontaneous Experimental Autoimmune Encephalomyelitis Is Linked to Human Multiple Sclerosis Risk Genes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Faber, Hans; Kurtoic, Dunja; Krishnamoorthy, Gurumoorthy; Weber, Peter; Pütz, Benno; Müller-Myhsok, Bertram; Weber, Frank; Andlauer, Till F M
Abstract:
Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expression profiling to study whether spontaneous opticospinal EAE (OSE) or MOG-induced EAE mirrors the genetic contribution to the pathogenesis of multiple sclerosis more faithfully. T...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2020
Band / Volume:
11
Volltext / DOI:
doi:10.3389/fimmu.2020.02165
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33072080
Print-ISSN:
1664-3224
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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