Expression of soluble receptor for advanced glycation end products is associated with disease severity in congenital diaphragmatic hernia.

Kipfmueller, Florian; Heindel, Katrin; Geipel, Annegret; Berg, Christoph; Bartmann, Peter; Reutter, Heiko; Mueller, Andreas; Holdenrieder, Stefan

doi:10.1152/ajplung.00359.2018

2019

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Title:: Expression of soluble receptor for advanced glycation end products is associated with disease severity in congenital diaphragmatic hernia.
Document type:: Article; Journal Article
Author(s):: Kipfmueller, Florian; Heindel, Katrin; Geipel, Annegret; Berg, Christoph; Bartmann, Peter; Reutter, Heiko; Mueller, Andreas; Holdenrieder, Stefan
Abstract:: Pulmonary hypertension (PH) and lung hypoplasia are major contributors to morbidity and mortality in newborns with congenital diaphragmatic hernia (CDH). The soluble receptor for advanced glycation end products (sRAGE) is a marker of endothelial function and might be associated with disease severity in CDH newborns. In a cohort of 30 CDH newborns and 20 healthy control newborns, sRAGE concentration was measured at birth and at 6 h, 12 h, 24 h, 48 h, and 7-10 days. In healthy newborns, sRAGE was significantly higher at birth and at 48 h compared with CDH newborns (both P < 0.001). Among CDH newborns, sRAGE was significantly lower at birth (P = 0.033) and at 7-10 days (P = 0.035) in patients receiving extracorporeal membrane oxygenation (ECMO) compared with patients not receiving ECMO. In contrast, CDH newborns receiving ECMO had significantly higher values at 6 h (P = 0.001), 12 h (P = 0.004), and 48 h (0.032). Additionally, sRAGE correlated significantly with PH severity, intensity and duration of mechanical ventilation, and prenatally assessed markers of CDH severity (lung size, liver herniation). The probability to receive ECMO therapy was five times higher in CDH newborns with sRAGE concentrations below the calculated cutoff of 650 pg/ml at birth (P = 0.002) and nine times higher in CDH newborns with sRAGE concentrations above the cutoff of 3,500 pg/ml at 6 h (P = 0.001). These findings suggest a potential involvement of sRAGE in the pathophysiology of CDH and may act as a therapeutic target in future treatment approaches.
Journal title abbreviation:: Am J Physiol Lung Cell Mol Physiol
Year:: 2019
Journal volume:: 316
Journal issue:: 6
Pages contribution:: L1061-L1069
Fulltext / DOI:: doi:10.1152/ajplung.00359.2018
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/30838867
Print-ISSN:: 1040-0605
TUM Institution:: Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Institut für Laboratoriumsmedizin (DHM) (Prof. Holdenrieder)2019