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Titel:

Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts.

Dokumenttyp:
Journal Article
Autor(en):
Hoberg, M; Rudert, M; Pap, T; Klein, G; Gay, S; Aicher, WK
Abstract:
BACKGROUND: In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported. Aim: To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to laminin-1 (LM-111) and in the presence or absence of costimulatory signals provided by transforming growth factor beta (TGFbeta). METHODS: SFs were seeded in laminin-coated flasks...     »
Zeitschriftentitel:
Ann Rheum Dis
Jahr:
2007
Band / Volume:
66
Heft / Issue:
4
Seitenangaben Beitrag:
446-51
Sprache:
eng
Volltext / DOI:
doi:10.1136/ard.2006.060228
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17124250
Print-ISSN:
0003-4967
TUM Einrichtung:
Klinik und Poliklinik für Orthopädie und Sportorthopädie
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