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Title:

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Day, JW; Gelfanov, V; Smiley, D; Carrington, PE; Eiermann, G; Chicchi, G; Erion, MD; Gidda, J; Thornberry, NA; Tschöp, MH; Marsh, DJ; SinhaRoy, R; DiMarchi, R; Pocai, A
Abstract:
The ratio of GLP-1/glucagon receptor (GLP1R/GCGR) co-agonism that achieves maximal weight loss without evidence of hyperglycemia was determined in diet-induced obese (DIO) mice chronically treated with GLP1R/GCGR co-agonist peptides differing in their relative receptor agonism. Using glucagon-based peptides, a spectrum of receptor selectivity was achieved by a combination of selective incorporation of GLP-1 sequences, C-terminal modification, backbone lactam stapling to stabilize helical structu...     »
Journal title abbreviation:
Biopolymers
Year:
2012
Journal volume:
98
Journal issue:
5
Pages contribution:
443-50
Fulltext / DOI:
doi:10.1002/bip.22072
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23203689
Print-ISSN:
0006-3525
TUM Institution:
Kliniken und Institute
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