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Title:

High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Stemmer, K; Perez-Tilve, D; Ananthakrishnan, G; Bort, A; Seeley, RJ; Tschöp, MH; Dietrich, DR; Pfluger, PT
Abstract:
Obesity and concomitant comorbidities have emerged as public health problems of the first order. For instance, obese individuals have an increased risk for kidney cancer. However, direct mechanisms linking obesity with kidney cancer remain elusive. We hypothesized that diet-induced obesity (DIO) promotes renal carcinogenesis by inducing an inflammatory and tumor-promoting microenvironment. We compared chow-fed lean Wistar rats with those that were sensitive (DIOsens) or partially resistant (DIOr...     »
Journal title abbreviation:
Dis Model Mech
Year:
2012
Journal volume:
5
Journal issue:
5
Pages contribution:
627-35
Fulltext / DOI:
doi:10.1242/dmm.009407
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22422828
Print-ISSN:
1754-8403
TUM Institution:
Kliniken und Institute
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