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Title:

Obesity is associated with hypothalamic injury in rodents and humans.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Author(s):
Thaler, JP; Yi, CX; Schur, EA; Guyenet, SJ; Hwang, BH; Dietrich, MO; Zhao, X; Sarruf, DA; Izgur, V; Maravilla, KR; Nguyen, HT; Fischer, JD; Matsen, ME; Wisse, BE; Morton, GJ; Horvath, TL; Baskin, DG; Tschöp, MH; Schwartz, MW
Abstract:
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of HFD onset, prior to substantial weight gain. Furthermore, both reactive gliosis and markers suggestive of neuron in...     »
Journal title abbreviation:
J Clin Invest
Year:
2012
Journal volume:
122
Journal issue:
1
Pages contribution:
153-62
Fulltext / DOI:
doi:10.1172/JCI59660
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22201683
Print-ISSN:
0021-9738
TUM Institution:
Kliniken und Institute
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