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Titel:

Obesity is associated with hypothalamic injury in rodents and humans.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Autor(en):
Thaler, JP; Yi, CX; Schur, EA; Guyenet, SJ; Hwang, BH; Dietrich, MO; Zhao, X; Sarruf, DA; Izgur, V; Maravilla, KR; Nguyen, HT; Fischer, JD; Matsen, ME; Wisse, BE; Morton, GJ; Horvath, TL; Baskin, DG; Tschöp, MH; Schwartz, MW
Abstract:
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of HFD onset, prior to substantial weight gain. Furthermore, both reactive gliosis and markers suggestive of neuron in...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2012
Band / Volume:
122
Heft / Issue:
1
Seitenangaben Beitrag:
153-62
Volltext / DOI:
doi:10.1172/JCI59660
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22201683
Print-ISSN:
0021-9738
TUM Einrichtung:
Kliniken und Institute
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