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Titel:

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Day, JW; Gelfanov, V; Smiley, D; Carrington, PE; Eiermann, G; Chicchi, G; Erion, MD; Gidda, J; Thornberry, NA; Tschöp, MH; Marsh, DJ; SinhaRoy, R; DiMarchi, R; Pocai, A
Abstract:
The ratio of GLP-1/glucagon receptor (GLP1R/GCGR) co-agonism that achieves maximal weight loss without evidence of hyperglycemia was determined in diet-induced obese (DIO) mice chronically treated with GLP1R/GCGR co-agonist peptides differing in their relative receptor agonism. Using glucagon-based peptides, a spectrum of receptor selectivity was achieved by a combination of selective incorporation of GLP-1 sequences, C-terminal modification, backbone lactam stapling to stabilize helical structu...     »
Zeitschriftentitel:
Biopolymers
Jahr:
2012
Band / Volume:
98
Heft / Issue:
5
Seitenangaben Beitrag:
443-50
Volltext / DOI:
doi:10.1002/bip.22072
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23203689
Print-ISSN:
0006-3525
TUM Einrichtung:
Kliniken und Institute
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