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Titel:

High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Stemmer, K; Perez-Tilve, D; Ananthakrishnan, G; Bort, A; Seeley, RJ; Tschöp, MH; Dietrich, DR; Pfluger, PT
Abstract:
Obesity and concomitant comorbidities have emerged as public health problems of the first order. For instance, obese individuals have an increased risk for kidney cancer. However, direct mechanisms linking obesity with kidney cancer remain elusive. We hypothesized that diet-induced obesity (DIO) promotes renal carcinogenesis by inducing an inflammatory and tumor-promoting microenvironment. We compared chow-fed lean Wistar rats with those that were sensitive (DIOsens) or partially resistant (DIOr...     »
Zeitschriftentitel:
Dis Model Mech
Jahr:
2012
Band / Volume:
5
Heft / Issue:
5
Seitenangaben Beitrag:
627-35
Volltext / DOI:
doi:10.1242/dmm.009407
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22422828
Print-ISSN:
1754-8403
TUM Einrichtung:
Kliniken und Institute
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