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Titel:

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.

Dokumenttyp:
Journal Article
Autor(en):
Coassin, Stefan; Hermann-Kleiter, Natascha; Haun, Margot; Wahl, Simone; Wilson, Rory; Paulweber, Bernhard; Kunze, Sonja; Meitinger, Thomas; Strauch, Konstantin; Peters, Annette; Waldenberger, Melanie; Kronenberg, Florian; Lamina, Claudia
Abstract:
Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has not been addressed yet. Therefore, we conducted an epigenome-wide analysis of DNA methylation on Lp(a) levels in two population-based studies (total n = 2208). We identified a CpG site in the LPA promoter which was significantly associated with Lp(a)...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2020
Band / Volume:
15
Heft / Issue:
4
Volltext / DOI:
doi:10.1371/journal.pone.0232073
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32343731
Print-ISSN:
1932-6203
TUM Einrichtung:
656; 658; Institut für Humangenetik
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