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Title:

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mroz, Piotr A; Finan, Brian; Gelfanov, Vasily; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D; Perez-Tilve, Diego
Abstract:
OBJECTIVE: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. METHODS: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated and characterized in vitro using functional assays in cell systems overexpressing human and mouse derived receptors. These analogs were characterized in vivo in DIO mice following acute dosing for eff...     »
Journal title abbreviation:
Mol Metab
Year:
2019
Journal volume:
20
Pages contribution:
51-62
Fulltext / DOI:
doi:10.1016/j.molmet.2018.12.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30578168
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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