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Title:

Recognizing the Molecular Multifunctionality and Interactome of TIMP-1.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Grünwald, Barbara; Schoeps, Benjamin; Krüger, Achim
Abstract:
Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a major player in preserving tissue integrity and has recently also emerged as a decisive factor in several human pathologies. This appreciation has prompted this review addressing the largely underestimated complexity of the functions executed by TIMP-1 and their mechanistic basis. In fact, the versatile impact of TIMP-1 on cellular functions stems from its two-domain structure harboring metalloproteinase-inhibitory and cytokine-like signaling...     »
Journal title abbreviation:
Trends Cell Biol
Year:
2019
Journal volume:
29
Journal issue:
1
Pages contribution:
6-19
Fulltext / DOI:
doi:10.1016/j.tcb.2018.08.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30243515
Print-ISSN:
0962-8924
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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