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Title:

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Melnik, Svitlana; Werth, Nadine; Boeuf, Stephane; Hahn, Eva-Maria; Gotterbarm, Tobias; Anton, Martina; Richter, Wiltrud
Abstract:
BACKGROUND: Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a process of MSC propagation in cell culture for therapeutic applications. Expansion protocols could preselect MSC with elevated levels of growth-promoting transcription factors with oncogenic potential, such...     »
Journal title abbreviation:
Stem Cell Res Ther
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13287-019-1187-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30836996
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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